Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types슈퍼 대화식 프로모터는 혈액 계통 세포 유형에서 세포 유형-특이 적 조절 네트워크에 대한 통찰력을 제공Research Article Published on 2022-01-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis analysis ATAC-seq binding Blood blood cell Blood cells capture CD4 Cell cell type cell types chromatin compendium complex Critical disrupt driven by enhancer enhancers EPHB3 ETS1 explain Express expression level FIVE Follow-up functional Genetic variant GWAS GWAS variant GWAS variants help hematological hypothese identify implication include independent Interaction interactions interactivity Interpretation Lineage locus lymphocyte Lymphocyte count motifs norm overlap Phenotypes PIR Platelet Platelet count promoter promoters provide redundancy Region regions Regulatory regulatory network regulatory region resource strong interactions traits transcription factor transcriptional transcriptional regulation variant variants [DOI] 10.1371/journal.pgen.1009984 PMC 바로가기 [Article Type] Research Article
Prioritisation of Candidate Genes Underpinning COVID-19 Host Genetic Traits Based on High-Resolution 3D Chromosomal TopologyGenetics Published on 2021-10-252022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] 3D chromosomal architecture applied approach arising association authors Blood Brain candidate capture cells chromosomal COVID-19 COVID-19 pathology COVID-19 susceptibility disease DNA enhancers and promoters experiments expressed Genome-wide association study GWAS GWAS (genome-wide association studies) GWAS meta-analysis GWAS variant High-resolution Inflammatory response Interaction interactions involved lung carcinoma Pathways primary cell type putative target gene Region regions regulate Regulatory regulatory genome severity statistical tissues traits variant viral infection [DOI] 10.3389/fgene.2021.745672 PMC 바로가기 [Article Type] Genetics